Rapid diagnosis of Talaromyces marneffei infection by metagenomic next-generation sequencing technology in a Chinese cohort of inborn errors of immunity

Talaromyces marneffei (T.marneffei) is an opportunistic pathogen.Patients with inborn errors of immunity (IEI) have been increasingly diagnosed with T.marneffei in recent years.The disseminated infection of T.marneffei can be life-threatening without timely and effective antifungal therapy.Rapid and accurate pathogenic microbiological diagnosis is

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Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells

Abstract Bis(monoacylglycero)phosphate (BMP) is a major phospholipid constituent of intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation and sorting of lipid cargo.Recent observations suggest that the Batten disease-associated protein CLN5 functions as lysosomal BMP synthase.Here, we show that Gloves transacylation

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